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Vitamin E supplementation for prevention of morbidity and mortality in preterm infants

Vitamin E supplementation for prevention of morbidity and mortality in preterm infants

Kolkata, Oct 4 (UNI) Vitamin E, comprising eight biologically active tocopherols, is an

important antioxidant for the health and wellbeing of premature neonates.

It helps in scavenging free radicals, thereby reducing the risk of lipid peroxidation and

oxidant injury in preterm infants.

However, to achieve these effects, higher serum levels of tocopherols are needed

than those reached through routinely recommended oral doses of vitamin E. This

underlined the need to evaluate higher doses of vitamin E supplementation to eliminate

or reduce the risk of conditions such as retinopathy of prematurity (ROP). Randomized

controlled trials evaluating the efficacy of such high-dose supplementation have not

been uniformly encouraging.

On the other hand, there have been reports of serious toxicity following megavitamin E

supplements in preterm infants. The primary objective of this Cochrane review was to

evaluate the spectrum of benefits and risks of vitamin E supplementation in preterm infants.

Trials that randomized preterm infants or those with a birth weight < 2500 g to

supplementation with vitamin E (intervention) or placebo/no treatment were eligible for

inclusion in the review.

Studies were included regardless of the vitamin E content of the infant’s feedings

(human or formula milk) or the route of vitamin E supplementation (parenteral or oral).

The reviewers excluded studies in which vitamin E had been provided as a co-intervention.

The primary outcome measures included mortality until discharge from hospital,

combined outcome at 18 months including mortality (bronchopulmonary dysplasia,

blindness, mental retardation or cerebral palsy, and mortality), and combined outcome

at 18 months excluding mortality.

The major secondary outcomes were sepsis, severe intraventricular haemorrhage

(IVH) (grade III or IV), severe ROP, necrotizing enterocolitis with gastrointestinal

perforation, signs of haemolysis, and local reaction at the injection site.

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10 Dec 2018 | 12:53 PM

Kolkata, Dec 10 (UNI) Aflatoxins are poisonous substances produced by certain kinds of fungi (moulds) that are found naturally all over the world; they can contaminate food crops and pose a serious health threat to humans and livestock.

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Is your leg under attack? Know from the specialist

Is your leg under attack? Know from the specialist

06 Dec 2018 | 11:17 AM

Kolkata, Dec 6 (UNI) We stand tall on our feet all day long, walk and run around to get our chores done, and yet our legs are perhaps the most neglected body part.

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World’s first human telerobotic coronary intervention surgery in Ahmedabad

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05 Dec 2018 | 8:18 PM

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Leadless pacemaker successfully implanted in a 74 year-old morbidly obese patient suffering from transiet loss of consciousness

Leadless pacemaker successfully implanted in a 74 year-old morbidly obese patient suffering from transiet loss of consciousness

03 Dec 2018 | 1:48 PM

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Annual incidence of head and neck cancers worldwide more than 550,000 cases

Annual incidence of head and neck cancers worldwide more than 550,000 cases

03 Dec 2018 | 11:43 AM

Kolkata, Dec 3 (UNI) The annual incidence of head and neck cancers worldwide is more than 550,000 cases with around 300,000 deaths each year.

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