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Paediatric chewable medicine promises improved treatment against intestinal worms

Paediatric chewable medicine promises improved treatment against intestinal worms

Geneva, Jun 23 (UNI) The World Health Organization (WHO) will begin distributing a paediatric (chewable) formulation of mebendazole to countries with a high prevalence of soil-transmitted helminthiases (intestinal worms).
Mebendazole is one of the medicines recommended by WHO to treat intestinal worm infections of humans. This formulation was approved by the United States Food and Drug Administration in 2016 and is now donated to WHO by the pharmaceutical company Johnson & Johnson.
“Now, young children aged 1 year or older children who have difficulty swallowing solid tablets will be able to easily ingest the tablet, which has a pleasant taste and can either be chewed or turned into a soft mass with a little water,” said Dr Antonio Montresor, who heads WHO’s programme on soil-transmitted helminthiasis.
Initially, the quantity of this paediatric formulation will be limited, with full roll-out planned as production capability increases. Paediatric mebendazole will fill a major gap in the treatment of intestinal worms.
“The new formulation was developed in response to WHO’s call for a more child-friendly version. It overcomes a major difficulty in administering the medicine to children,” said Cori Vail, Director of Program Strategy for Soil Transmitted Helminths at Johnson & Johnson.
More than 1.5 billion people, or 24 per cent of the world’s population, are infected with soil-transmitted helminths worldwide. Infections are widely distributed in tropical and subtropical areas, with the greatest numbers occurring in sub-Saharan Africa, the Americas, China and East Asia.
Over 267 million preschool-age children live in areas where these parasitic worms are intensively transmitted and periodic treatment is required to prevent associated morbidity.
In 2017, WHO published an updated, evidence-based guideline on regular large-scale treatment of population groups at risk of soil-transmitted helminth infections. The guideline largely endorses the current practice of preventive treatment in areas endemic for the three main worm species that cause the disease.
Recognizing that preschool children are an important group at risk for intestinal worms, the pharmaceutical company Johnson & Johnson have decided to include the new formulation in their current donation programme through WHO, with plans to gradually increase production.
Johnson & Johnson have collaborated with WHO to deliver quality-assured mebendazole to control soil-transmitted helminth infections in school-age children since 2010. More than 1 billion tablets of donated mebendazole (500 mg) have been shipped to countries requesting the medicine.
WHO invites countries that are facing difficulties in procuring deworming (anthelminthic) medicines and are planning to conduct large-scale treatment campaigns for preschool children in 2019 to submit their requests for paediatric mebendazole to the WHO Department of Control of Neglected Tropical Diseases before 31 August 2018. Specific requests can be submitted alongside those for other preventive medicines for treatment of neglected tropical diseases.
Soil-transmitted helminthiases are among the most common infections worldwide and affect the poorest and most deprived communities. They are caused by infection with nematodes (worms), the commonest of which are the roundworm (Ascaris lumbricoides), the whipworm (Trichuris trichiura) and the hookworms (Ancylostoma duodenale and Necator americanus).
Helminths are transmitted by microscopic eggs that are passed in the faeces of infected people. Adult worms live in the intestine where they produce thousands of eggs each day. In areas where sanitation is inadequate, the eggs excreted in human faeces contaminate the soil.
Periodic anthelminthic treatment reduces and maintains low intensity of infection but, in the longer term, provision of adequate sanitation is fundamental to break the cycle of infection and reinfection and sustainably control these infections. Health and hygiene education can also help in reducing transmission and reinfection.
UNI XC-BM SB 0918

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