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States » SouthPosted at: Jan 17 2022 1:55AM


RGCB sheds light on heart disease risk reduction in patients with diabetes

Thiruvananthapuram, Jan 16 (UNI) Researchers at the Rajiv Gandhi Centre for Biotechnology (RGCB) here have identified Cyclophilin A, a protein which is a known player in several human diseases, as a potential drug target for reducing risk of heart disease in patients with diabetes.
Heart attacks result from rupture of cholesterol plaque deposited on walls of arteries. A tear or rupture in the plaque would activate a repairing mechanism resulting in a blood clot. Such clots can completely block blood flow to the heart muscle and cause a heart attack.
"Patients with diabetes mellitus have increased risk of vascular disease and are prone to ruptures. Our research has shown that Cyclophilin A plays a major role in increasing the risk," Dr. Surya Ramachandran, a program scientist with the Cardiovascular Diseases and Diabetes Biology lab, RGCB, said in a press release here on Sunday.
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