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Science & Technology Share

Circassia gives up on allergy after house dust mite study fails"

Circassia gives up on allergy after house dust mite study fails"

LONDON, Apr 18 (Reuters) Britain's Circassia Pharmaceuticals is throwing in the towel on allergy investment after a second high-profile clinical trial flop, focusing instead on building a broader respiratory business.
The failure of the company's immunotherapy to perform better than placebo in fighting dust mite allergy in a Phase IIb test follows similar negative results in a Phase III trial against cat allergy last year.
The company's stock lost two-third's of its value in a single session on the June 2016 cat results, which many investors feared undermined the allergy thesis, and the reaction on Tuesday was more muted, with shares losing around 3 percent.
In both cases, the company said, the immunotherapy failed because of a marked placebo effect among patients not on therapy.
The top shareholders in Circassia, which listed on the London stock market in March 2014 in Britain's largest biotech flotation for decades, are Invesco and Neil Woodford's investment management company, both big backers of UK science.
Woodford suffered another setback earlier this month when Allied Minds, which commercialises ideas from universities, announced a large writedown.
Circassia Chief Executive Steve Harris said he was "naturally disappointed" by the dust mite study failure.
"We remain convinced that the technology has biologic activity, but we also believe the difficulty in overcoming the placebo effect using the field study designs required by regulators represents a significant hurdle, and consequently we will make no further investment in our allergy portfolio," he said.
Instead, Circassia will concentrate on its wider respiratory business, in particular a new U.
S.
commercial collaboration with AstraZeneca.
Circassia last month secured U.
S.
rights from AstraZeneca for two drugs to treat chronic obstructive pulmonary disease for up to $230 million.
REUTERS RJ

History

History of modern transfusion medicine

Kolkata, Sep 15 (UNI) The Medical Officer Incharge (MOIC) Blood Bank, Fortis Hospitals, Anandapur here, Dr Avijit Dev today said in ancient literature, there are descriptions of blood oozing and death of suffering humanity owing to that everybody gets a panic whenever sees a person bleeding profusely in front of him.

Lupin

Lupin receives FDA approval for generic Flagyl® Tablets

Mumbai, Sep 13 (UNI) Pharma Major Lupin announced that it has received final approval for its Metronidazole Tablets USP, 250 mg and 500 mg from the United States Food and Drug Administration (FDA) to market a generic version of G.

Glaucoma

Glaucoma is vision thief, Cataract is sight killer: Experts

By Rishira Jain New Delhi, Sep 11 (UNI) Health experts from various eye institutes have blamed Cataract and Glaucoma for around 70 per cent of all eye-related diseases in the country, leading to either temporary or permanent blindness.

Eliminate

Eliminate Hepatitis from S East Asia: Amitabh Bachchan

New Delhi, Sep 8 (UNI) Making a passionate plea to eliminate viral hepatitis from the South-East Asia region, Bollywood superstar Amitabh Bachchan, World Health organisation Goodwill Ambassador for Hepatitis in the region , today stressed need for increasing awareness about the preventable disease and ending discrimination against those affected.

Ajanta

Ajanta Pharma receives final approval from USFDA for Entacapone Tablets

Mumbai, Sep4 (UNI)Pharma Major, Ajanta Pharma has received final approval from US Food and Drug Administration (USFDA) for Entacapone Tablets.

History of modern transfusion medicine

History of modern transfusion medicine

Kolkata, Sep 15 (UNI) The Medical Officer Incharge (MOIC) Blood Bank, Fortis Hospitals, Anandapur here, Dr Avijit Dev today said in ancient literature, there are descriptions of blood oozing and death of suffering humanity owing to that everybody gets a panic whenever sees a person bleeding profusely in front of him.

Solar eclipse 2017: North America will witness total solar eclipse

Solar eclipse 2017: North America will witness total solar eclipse

New York, Aug 21 (UNI) Today, all of North America will witness a total solar eclipse for the first time in 99 years, where the Moon will pass in front of the Sun, casting darkness across swathes of the Earth's surface - with up to 14 states shrouded in complete blackout.

Nano-particle fertilizer could lead to new 'green revolution'

Nano-particle fertilizer could lead to new 'green revolution'

New Delhi, Jan 26 (UNI) Sri Lankan scientists report having developed a simple way to make a benign, more efficient fertilizer – described as nano-particle fertilizer - that could contribute to a second food revolution across the globe.

Broken pebbles offer clues to Palaeolithic funeral rituals

Broken pebbles offer clues to Palaeolithic funeral rituals

New Delhi, Feb 9 (UNI) Humans may have ritualistically "killed" objects to remove their symbolic power, some 5,000 years earlier than previously thought, a new international study of marine pebble tools from an Upper Palaeolithic burial site in Italy suggests.

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