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  • Vikram Phadnis' directorial debut 'Hrudayantar' to be showcased at Goa Marathi Film Festival
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Science & Technology Share

Circassia gives up on allergy after house dust mite study fails"

Circassia gives up on allergy after house dust mite study fails"

LONDON, Apr 18 (Reuters) Britain's Circassia Pharmaceuticals is throwing in the towel on allergy investment after a second high-profile clinical trial flop, focusing instead on building a broader respiratory business.
The failure of the company's immunotherapy to perform better than placebo in fighting dust mite allergy in a Phase IIb test follows similar negative results in a Phase III trial against cat allergy last year.
The company's stock lost two-third's of its value in a single session on the June 2016 cat results, which many investors feared undermined the allergy thesis, and the reaction on Tuesday was more muted, with shares losing around 3 percent.
In both cases, the company said, the immunotherapy failed because of a marked placebo effect among patients not on therapy.
The top shareholders in Circassia, which listed on the London stock market in March 2014 in Britain's largest biotech flotation for decades, are Invesco and Neil Woodford's investment management company, both big backers of UK science.
Woodford suffered another setback earlier this month when Allied Minds, which commercialises ideas from universities, announced a large writedown.
Circassia Chief Executive Steve Harris said he was "naturally disappointed" by the dust mite study failure.
"We remain convinced that the technology has biologic activity, but we also believe the difficulty in overcoming the placebo effect using the field study designs required by regulators represents a significant hurdle, and consequently we will make no further investment in our allergy portfolio," he said.
Instead, Circassia will concentrate on its wider respiratory business, in particular a new U.
S.
commercial collaboration with AstraZeneca.
Circassia last month secured U.
S.
rights from AstraZeneca for two drugs to treat chronic obstructive pulmonary disease for up to $230 million.
REUTERS RJ

Mumbai

Mumbai sees 20 organ donations in five months

Thane, May 25 (UNI) Mumbai witnessed its 20th cadaver organ donation this month when the family of a 24-year-old brain-dead girl, consented to donate her heart, kidneys and liver.

Over

Over 300 cases of diarrohea diagnosed in Poonch, health staff on alert

Jammu, May 23 (UNI) Over 300 cases of diarrohea in the past one-week were reported in bordering belt of Poonch district of Jammu and Kashmir, while the district administration has sounded an alert and cancelled the leaves of health officials.

Suspected

Suspected Ebola cases in Congo rise to 29 - WHO

GENEVA, May 19 (Reuters) The number of suspected Ebola cases in Congo has risen to 29, up from 21, World Health Organization spokesman Christian Lindmeier told a regular UN briefing in Geneva today.

Punjab

Punjab launches campaign to sensitise people about ill effect of hypertension

Chandigarh, May 18 (UNI) The Punjab Health department today commenced a consistence awareness campaign to drive home the citizens of the state about the healthy lifestyle practices besides sensitising them about the ill effects of hypertension.

2

2 more test positive for swine flu in Kangra

Kangra, May 16 (UNI) Two more patients have tested positive for Swine Flu in Kangra district's Dr Rajinder Prasad Govt Medical College Tanda.

Nano-particle fertilizer could lead to new 'green revolution'

Nano-particle fertilizer could lead to new 'green revolution'

New Delhi, Jan 26 (UNI) Sri Lankan scientists report having developed a simple way to make a benign, more efficient fertilizer – described as nano-particle fertilizer - that could contribute to a second food revolution across the globe.

Broken pebbles offer clues to Palaeolithic funeral rituals

Broken pebbles offer clues to Palaeolithic funeral rituals

New Delhi, Feb 9 (UNI) Humans may have ritualistically "killed" objects to remove their symbolic power, some 5,000 years earlier than previously thought, a new international study of marine pebble tools from an Upper Palaeolithic burial site in Italy suggests.

Fiscal incentives may help reduce emissions in developing countries

Fiscal incentives may help reduce emissions in developing countries

New Delhi, Feb 7 (UNI) Fiscal policies introduced by the Governments in developing countries can have a significant effect on lowering harmful carbon emissions and help countries with fulfilling their commitments under the UNFCCC Paris Agreement, a study has found.

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