Wednesday, Apr 26 2017 | Time 00:01 Hrs(IST)
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Science & Technology Share

Circassia gives up on allergy after house dust mite study fails"

Circassia gives up on allergy after house dust mite study fails"

LONDON, Apr 18 (Reuters) Britain's Circassia Pharmaceuticals is throwing in the towel on allergy investment after a second high-profile clinical trial flop, focusing instead on building a broader respiratory business.
The failure of the company's immunotherapy to perform better than placebo in fighting dust mite allergy in a Phase IIb test follows similar negative results in a Phase III trial against cat allergy last year.
The company's stock lost two-third's of its value in a single session on the June 2016 cat results, which many investors feared undermined the allergy thesis, and the reaction on Tuesday was more muted, with shares losing around 3 percent.
In both cases, the company said, the immunotherapy failed because of a marked placebo effect among patients not on therapy.
The top shareholders in Circassia, which listed on the London stock market in March 2014 in Britain's largest biotech flotation for decades, are Invesco and Neil Woodford's investment management company, both big backers of UK science.
Woodford suffered another setback earlier this month when Allied Minds, which commercialises ideas from universities, announced a large writedown.
Circassia Chief Executive Steve Harris said he was "naturally disappointed" by the dust mite study failure.
"We remain convinced that the technology has biologic activity, but we also believe the difficulty in overcoming the placebo effect using the field study designs required by regulators represents a significant hurdle, and consequently we will make no further investment in our allergy portfolio," he said.
Instead, Circassia will concentrate on its wider respiratory business, in particular a new U.
S.
commercial collaboration with AstraZeneca.
Circassia last month secured U.
S.
rights from AstraZeneca for two drugs to treat chronic obstructive pulmonary disease for up to $230 million.
REUTERS RJ

Bengal

Bengal Govt to launch app on blood donors

Kolkata, Apr 25 (UNI) To ensure information about availability of blood is available at one’s fingertips, the Bengal Health Department and the State AIDS Prevention and Control Society (SACS) have come together to create an innovative app.

Bengal

Bengal Govt to launch app on blood donors

Kolkata, Apr 25 (UNI) To ensure information about availability of blood is available at one’s fingertips, the Bengal Health Department and the State AIDS Prevention and Control Society (SACS) have come together to create an innovative app.

Ghana,

Ghana, Kenya and Malawi to pilot GSK malaria vaccine from 2018

LONDON, Apr 24 (Reuters) Ghana, Kenya and Malawi will pilot the world's first malaria vaccine from 2018, offering it for babies and children in high-risk areas as part of real-life trials, the World Health Organization said today.

Ghana,

Ghana, Kenya and Malawi to pilot GSK malaria vaccine from 2018

LONDON, Apr 24 (Reuters) Ghana, Kenya and Malawi will pilot the world's first malaria vaccine from 2018, offering it for babies and children in high-risk areas as part of real-life trials, the World Health Organization said today.

Hypertension

Hypertension a silent killer: Dr Jayapraksh Sai

Hyderabad, Apr 22 (UNI) Hypertension is known as a "silent killer" because it has no obvious symptoms and many people are unaware that they have it, Apollo Sugar Clinics Consultant Diabetologist Dr Jayaprakash Sai said.

Hypertension

Hypertension a silent killer: Dr Jayapraksh Sai

Hyderabad, Apr 22 (UNI) Hypertension is known as a "silent killer" because it has no obvious symptoms and many people are unaware that they have it, Apollo Sugar Clinics Consultant Diabetologist Dr Jayaprakash Sai said.

TN

TN govt to manufacture and sell vitamins-rich health drink 'Neera'

Chennai, Apr 21 (UNI) Tamil Nadu would manufacture and sell vitamins-rich health drink 'Neera', a non-alcoholic drink extracted from toddy palms and coconut tress, in a big way.

TN

TN govt to manufacture and sell vitamins-rich health drink 'Neera'

Chennai, Apr 21 (UNI) Tamil Nadu would manufacture and sell vitamins-rich health drink 'Neera', a non-alcoholic drink extracted from toddy palms and coconut tress, in a big way.

123

123 die of swine flu in Mah since January

Nashik, Apr 20 (UNI) As many as 123 patients have died of swine flu in Maharashtra since January while 631 positive case were reported, State Survey (epidemics) officer Dr Pradeep Atute said.

123

123 die of swine flu in Mah since January

Nashik, Apr 20 (UNI) As many as 123 patients have died of swine flu in Maharashtra since January while 631 positive case were reported, State Survey (epidemics) officer Dr Pradeep Atute said.

Nano-particle fertilizer could lead to new 'green revolution'

Nano-particle fertilizer could lead to new 'green revolution'

New Delhi, Jan 26 (UNI) Sri Lankan scientists report having developed a simple way to make a benign, more efficient fertilizer – described as nano-particle fertilizer - that could contribute to a second food revolution across the globe.

Broken pebbles offer clues to Palaeolithic funeral rituals

Broken pebbles offer clues to Palaeolithic funeral rituals

New Delhi, Feb 9 (UNI) Humans may have ritualistically "killed" objects to remove their symbolic power, some 5,000 years earlier than previously thought, a new international study of marine pebble tools from an Upper Palaeolithic burial site in Italy suggests.

Fiscal incentives may help reduce emissions in developing countries

Fiscal incentives may help reduce emissions in developing countries

New Delhi, Feb 7 (UNI) Fiscal policies introduced by the Governments in developing countries can have a significant effect on lowering harmful carbon emissions and help countries with fulfilling their commitments under the UNFCCC Paris Agreement, a study has found.

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