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Aspirin not effective against cancer, heart ailments: Study

Aspirin not effective against cancer, heart ailments: Study

Washington/Canberra, Sep 18 (UNI) Aspirin, the humble, round, white tablet, accredited with aiding healthy lifestyle and warding off fatal diseases like cancer and heart-related issues, has failed to impress the researchers, who found that daily low-dose of aspirin in healthy older adults, does not prolong a healthy, independent living (life free of dementia or persistent physical disability).
These initial findings from the ASPirin in Reducing Events in the Elderly (ASPREE) trial, partially supported by the National Institutes of Health, were published online on September 16 in three papers in The New England Journal of Medicine.
ASPREE is an international, randomized, double-blind, placebo-controlled trial that enrolled 19,114 older people (16,703 in Australia and 2,411 in the United States).
The study began in 2010 and enrolled participants aged 70 and older; 65 was the minimum age of entry for African-American and Hispanic individuals in the United States because of their higher risk for dementia and cardiovascular disease.
At study enrollment, ASPREE participants could not have dementia or a physical disability and had to be free of medical conditions requiring aspirin use. They were followed for an average of 4.7 years to determine outcomes.
"Clinical guidelines note the benefits of aspirin for preventing heart attacks and strokes in persons with vascular conditions such as coronary artery disease," said NIA Director Richard J Hodes, MD.
"The concern has been uncertainty about whether aspirin is beneficial for otherwise healthy older people without those conditions. This study shows why it is so important to conduct this type of research, so that we can gain a fuller picture of aspirin's benefits and risks among healthy older persons."
The team of scientists was led by John J McNeil, MBBS, Ph.D, head of the Department of Epidemiology and Preventive Health at Monash University, Melbourne, Australia, and Anne M Murray, MD, director of the Berman Center for Outcomes and Clinical Research at Hennepin Healthcare in Minneapolis.
The research was supported in part by the National Institute on Aging (NIA) and the National Cancer Institute (NCI), both parts of the NIH. The Australian component of the study also received funding from the Australian National Health and Medical Research Council and Monash University. Aspirin and placebo were supplied by Bayer, which had no other involvement with the study.
In the total study population, treatment with 100 mg of low-dose aspirin per day did not affect survival free of dementia or disability.
Among the people randomly assigned to take aspirin, 90.3 per cent remained alive at the end of the treatment without persistent physical disability or dementia, compared with 90.5 per cent of those taking a placebo. Rates of physical disability were similar, and rates of dementia were almost identical in both groups.
The group taking aspirin had an increased risk of death compared to the placebo group: 5.9 per cent of participants taking aspirin and 5.2 per cent taking placebo died during the study. This effect of aspirin has not been noted in previous studies; and caution is needed in interpreting this finding.
The higher death rate in the aspirin-treated group was due primarily to a higher rate of cancer deaths. A small increase in new cancer cases was reported in the group taking aspirin but the difference could have been due to chance.
The researchers also analysed the ASPREE results to determine whether cardiovascular events took place. They found that the rates for major cardiovascular events -- including coronary heart disease, non-fatal heart attacks, and fatal and nonfatal ischemic stroke -- were similar in the aspirin and the placebo groups.
In the aspirin group, 448 people experienced cardiovascular events, compared with 474 people in the placebo group. The investigators noted that aspirin was associated with a significantly increased risk of bleeding, primarily in the gastrointestinal tract and brain. "The increase in cancer deaths in study participants in the aspirin group was surprising, given prior studies suggesting aspirin use improved cancer outcomes," said Leslie Ford, MD, associate director for clinical research, NCI Division of Cancer Prevention.
"Analysis of all the cancer-related data from the trial is under way and until we have additional data, these findings should be interpreted with caution, Dr Ford told the Science Daily.
"Continuing follow-up of the ASPREE participants is crucial, particularly since longer term effects on risks for outcomes such as cancer and dementia may differ from those during the study to date," said Evan Hadley, MD, director of NIA's Division of Geriatrics and Clinical Gerontology.
"These initial findings will help to clarify the role of aspirin in disease prevention for older adults, but much more needs to be learned. The ASPREE team is continuing to analyse the results of this study and has implemented plans for monitoring participants," he added.

UNI XC RJ 1724

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